Chemokines in cardiac fibrosis
R Li, NG Frangogiannis - Current opinion in physiology, 2021 - Elsevier
… migration through CXCR3-independent effects that may involve proteoglycans (Neut, … may
directly stimulate fibroblast activation [41], in mouse cardiac fibroblasts, CCL2 stimulation had …
directly stimulate fibroblast activation [41], in mouse cardiac fibroblasts, CCL2 stimulation had …
Adding insult to injury-Inflammation at the heart of cardiac fibrosis
… cells modulating fibroblast function, cardiac fibroblasts are … protein components of the
myocardium during homeostasis, … fibrotic actions of CXCL10 operate through CXCR3-independent …
myocardium during homeostasis, … fibrotic actions of CXCL10 operate through CXCR3-independent …
Paired box 6 inhibits cardiac fibroblast differentiation
Y Feng, M Li, S Wang, W Cong, G Hu, Y Song… - Biochemical and …, 2020 - Elsevier
… Pax6 knockdown in CFs decreased CXC chemokine 10 (CXCL10… the predominant cell type
within the myocardium. Various … into the infarcted or hypertrophic regions of a stressed heart, …
within the myocardium. Various … into the infarcted or hypertrophic regions of a stressed heart, …
[HTML][HTML] Potential therapeutic manipulations of the CXCR3 chemokine axis for the treatment of inflammatory fibrosing diseases
MK Groover, JM Richmond - F1000Research, 2020 - ncbi.nlm.nih.gov
… domain plays no role in CXCL10 or CXCL11 binding or ligand-mediated internalization, but
this … in myocardium, which required CXCL10 fibroblast responses through proteoglycans 69 , …
this … in myocardium, which required CXCL10 fibroblast responses through proteoglycans 69 , …
T-cell regulation of fibroblasts and cardiac fibrosis
AD Bradshaw, KY DeLeon-Pennell - Matrix biology, 2020 - Elsevier
… This review will focus on T-cell recruitment to the myocardium and T-cell specific factors that
… likely through proteoglycan signaling [48]. In vitro, Cxcl10 did not modulate cardiac fibroblast …
… likely through proteoglycan signaling [48]. In vitro, Cxcl10 did not modulate cardiac fibroblast …
[HTML][HTML] XCR1+ conventional dendritic cell-induced CD4+ T helper 1 cell activation exacerbates cardiac remodeling after ischemic myocardial injury
H Inui, M Nishida, M Ichii, H Nakaoka, M Asaji… - … and Cellular Cardiology, 2023 - Elsevier
… coronary heart disease (CHD) and myocardial infarction (MI) [… − cells (Endothelial cell, Cardiac
fibroblast) and CD45 + cells (… ischemic myocardium via CXCR3 and CXCL9/CXCL10 axis. …
fibroblast) and CD45 + cells (… ischemic myocardium via CXCR3 and CXCL9/CXCL10 axis. …
Immune regulation of cardiac fibrosis post myocardial infarction
Y Zaidi, EG Aguilar, M Troncoso, DV Ilatovskaya… - Cellular signalling, 2021 - Elsevier
… The anti-fibrotic role of CXCL10 is believed to be due to inhibition of basic fibroblast …
cardiac fibroblasts led to decreased αSMA and Mmp3 expression and attenuated fibroblast-mediated…
cardiac fibroblasts led to decreased αSMA and Mmp3 expression and attenuated fibroblast-mediated…
GSK126 an inhibitor of epigenetic regulator EZH2 suppresses cardiac fibrosis by regulating the EZH2-PAX6-CXCL10 pathway
S Aziz, L Yalan, MA Raza, J Lemin… - … and Cell Biology, 2022 - cdnsciencepub.com
… progression of myocardial fibrosis in an EZH2-PAX6-CXCL10-… , CXCL10 is reported to play
a role in Ang-II-mediated … CXCL10 expression in cardiac fibroblast and mouse heart tissue …
a role in Ang-II-mediated … CXCL10 expression in cardiac fibroblast and mouse heart tissue …
Cxcl10 deficiency attenuates renal interstitial fibrosis through regulating epithelial-to-mesenchymal transition
… and cardiac fibrosis mainly through CXCR3-independent … growth and mediation of angiostatic
effects mainly through binding to … effects of CXCL10 were proved in myocardial infarct and …
effects mainly through binding to … effects of CXCL10 were proved in myocardial infarct and …
[HTML][HTML] Role of chemokine (C–X–C motif) ligand 10 (CXCL10) in renal diseases
J Gao, L Wu, S Wang, X Chen - Mediators of Inflammation, 2020 - hindawi.com
… CXCL10 can also function via CXCR3-independent pathways in vivo and in … of CXCL10 in
myocardial infarction are independent of CXCR3 and may be mediated through proteoglycan …
myocardial infarction are independent of CXCR3 and may be mediated through proteoglycan …